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目的:探讨早期中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)与急性一氧化碳中毒(ACOP)的相关性。方法:选取我院2015~2017年急诊医学部收治的ACOP患者178例为ACOP组,再根据病情分为轻、中、重度3亚组,另选取50名健康体检者为对照组,计算并比较各组NLR、PLR水平;采用Logistic回归分析观察早期NLR、PLR是否为ACOP的危险因素。结果:(1)ACOP组NLR、PLR水平均高于对照组(P<0.05)。(2)ACOP轻、中、重度3亚组NLR水平依次升高,差异有统计学意义。中、重度组PLR均高于轻度组(P<0.05),而中、重度组间PLR比较差异无统计学意义。(3)多项Logistic回归分析结果显示,PLR(OR重度=1.004,95%CI:1.000~1.010,P=0.031)及NLR(OR重度=2.420,95%CI:1.271~4.519,P=0.004)均为重度ACOP的独立危险因素。结论:早期NLR及PLR可反映ACOP的严重程度,重视NLR、PLR水平监测,有助于临床对ACOP的早期评估和干预,从而利于改善患者预后。
Objective: To investigate the correlation between early neutrophil / lymphocyte ratio (NLR), platelet / lymphocyte ratio (PLR) and acute carbon monoxide poisoning (ACOP). Methods: A total of 178 ACOP patients admitted to Department of Emergency Medicine from 2015 to 2017 in our hospital were selected as ACOP group. According to their condition, they were divided into mild, moderate and severe subgroups 3, and 50 healthy subjects were selected as control group. Group NLR, PLR levels; Logistic regression analysis of early NLR, PLR is a risk factor for ACOP. Results (1) The levels of NLR and PLR in ACOP group were higher than those in control group (P <0.05). (2) The levels of NLR in ACOP mild, moderate and severe subgroups increased in turn, the difference was statistically significant. The PLR of moderate and severe group were higher than that of mild group (P <0.05), while there was no significant difference in PLR between moderate and severe group. (3) The results of multiple logistic regression analysis showed that PLR (OR = 1.004, 95% CI: 1.000-1.010, P = 0.031) and NLR (OR = 2.420, 95% CI: 1.271-4.519, P = 0.004) Are independent risk factors for severe ACOP. Conclusion: Early NLR and PLR can reflect the severity of ACOP, attention to NLR, PLR level monitoring, contribute to the clinical assessment of early ACOP and intervention, which will help improve the prognosis of patients.