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用重庆麻鸭乙型肝炎动物模型，观察广西叶下珠体内抗鸭乙型肝炎病毒（ＤＨＢＶ）的作用。用广西叶下珠治疗１月，检测用药前后血清中的ＤＨＢＶ ＤＮＡ及转氨酶、肝组织病理等。广西叶下珠用药２周、１月能使血清ＤＨＢＶ ＤＮＡ总体水平显著降低（Ｐ＜０．０５或Ｐ＜０．０１），且停药后ＤＮＡ滴度回升不明显。血清转氨酶检查及肝脏常规ＨＥ染色病理检查未发现叶下珠对肝脏有明显的毒性损害。广西叶下珠在体内有抗鸭乙型肝炎病毒的作用。
Using Chongqing duckling hepatitis B animal model to observe the effect of Phyllanthus urinaria on Duck Hepatitis B virus (DHBV) in vivo. With Phyllanthuspylori treatment in January, before and after treatment of serum DHBV DNA and aminotransferase, liver histopathology. Phyllanthus urinaria for 2 weeks, January can make serum DHBV DNA overall level was significantly lower (P <0.05 or P <0.01), and withdrawal after DNA titer was not obvious. Serum aminotransferase and liver routine HE staining pathological examination showed no significant hypoxic damage to the liver. Guangxi Phyllanthus has the role of anti-duck hepatitis B virus in the body.