头孢替坦是半合成、非经肠的广谱头孢菌素,肌注或静脉给药1g,可保持较高的血药浓度、尿浓度及抗菌活性,并持续12 h 以上。这些特性使之治疗复合性尿路感染成为可能。19名复合性尿路感染,复合因素包括肾结石、糖尿病、IgA 肾病、马蹄肾、SLE 肾炎、多囊肾或行外科手术等。治疗前细菌学培养,共分离出34株菌株,其中27株在体外对头孢替坦敏感,其余抗药。菌种以大肠杆菌最 Cefotetan is a semi-synthetic, non-enteral broad-spectrum cephalosporins, intramuscular or intravenous administration of 1g, to maintain a high blood concentration, urinary concentration and antibacterial activity, and lasted more than 12 h. These features make it possible to treat multiple urinary tract infections. Nineteen patients had multiple urinary tract infections. The combined factors included kidney stones, diabetes mellitus, IgA nephropathy, horseshoe kidney disease, SLE nephritis, polycystic kidney disease or surgical operation. Bacterial culture before treatment, a total of 34 strains were isolated, of which 27 were sensitive to cefotetan in vitro, and the remaining drug-resistant. Strain to E. coli most