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目的通过观察全麻复合硬膜外麻和全麻对宫颈癌根治术患者围术期IL-6、TNF-α及S-100ββ的表达,研究两种麻醉方式对术后认知功能障碍的影响.方法选择宫颈癌根治术的患者46例,随机分为全麻复合硬膜外麻醉组(A组)和全麻组(B组),每组23例,分时点测定血清IL-6、TNF-α及S-100ββ的水平和患者MMSE评分.结果 IL-6、TNF-α、S-100ββ的表达,两组患者术前无统计学差异(P>0.05),术毕、术后6h、术后24h与术前比较均有统计学差异(P<0.05).A组患者IL-6、TNF-α的表达于术毕、术后6h两个时间点与B组患者比较有统计学差异,S-100ββ的表达仅术毕与B组患者有统计学差异(P<0.05).MMSE评分,术后6hA组明显高于B组(P0.05);A、B两组术后6h与术前、术后24h比较均显著降低(P0.05)on preoperative time, while there was significant difference compare preoperative time with operation finished、postoperative 6h、postoperative 24h (P<0.05),there was significant difference on the expression of IL-6、TNF-α at operation finished、postoperative 6h between group A and group B,the significant difference of the expression of S-100ββbetween group A and group B only at operation finished(P<0.05).To the MMSE score,group A was significant higher than group B at postoperative 6h(P0.05),and significant lower between the two groups compare postoperative 6h with preoperative time、postoperative 24h(P<0.05). Conclusion Combined general anesthesia and epidural anesthsia can reduce the postoperative early expression of IL-6、TNF-α、S-100ββ,the folow-up situation has nonthing to do with the way of anesthesia.