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目的:探讨戊酸雌二醇片联合黄体酮治疗围绝经期综合征的疗效。方法:选择2015年1月至2017年1月期间在我院接受治疗的150例围绝经期综合征的患者作为研究对象,按照随机数字法分为实验组(75例)与常规组(75例)。常规组采用常规治疗方案,实验组采用戊酸雌二醇片联合黄体酮进行治疗。对比两组患者的治疗效果并检查实验组患者的血清6项指标。结果:实验组患者的治疗总有效率(98.67%)显著高于常规组患者的治疗总有效率(88.00%),差异显著,具备统计学意义(P<0.05)。两组患者的不良反应发生情况无明显差异。实验组75例患者服用药物前和服用药物2个月、4个月、6个月相比,LH、FSH和T没有明显的变化(P>0.05),E2、P和PRL水平有明显的下降趋势(P<0.05)。结论:戊酸雌二醇片联合黄体酮治疗围绝经期综合征的疗效显著,可以有效的改善患者的激素状况,值得临床推广。
Objective: To investigate the efficacy of estradiol valerate tablets combined with progesterone in the treatment of perimenopausal syndrome. Methods: A total of 150 patients with climacteric syndrome who were treated in our hospital from January 2015 to January 2017 were selected as the research object. According to the random number method, 75 cases were divided into the experimental group (75 cases) ). Routine treatment with conventional regimen, the experimental group with estradiol valerate tablets combined with progesterone treatment. Compare the treatment effect of two groups of patients and check the serum of 6 patients in experimental group. Results: The total effective rate (98.67%) in the experimental group was significantly higher than that in the conventional group (88.00%), with significant difference (P <0.05). There was no significant difference in adverse reactions between the two groups. There were no significant changes in LH, FSH and T (P> 0.05), and the levels of E2, P and PRL in 75 patients in the experimental group before and after taking drugs for 2 months, 4 months and 6 months were significantly lower Trend (P <0.05). CONCLUSION: Estradiol valerate tablets combined with progesterone have a significant therapeutic effect on perimenopausal syndrome, which can effectively improve the hormone status of patients and deserve clinical promotion.