人绒毛膜促性腺激素(human chorionic gonadotropin,hCG)是由胎盘合体滋养细胞合成的一种糖蛋白激素,具有维持黄体寿命、刺激雌孕激素合成、抑制植物血凝素对淋巴细胞的增殖作用等功能。最近研究表明,胚胎移植前宫腔内灌注hCG可显著提高移植后的种植率和妊娠率,但其具体作用机制尚未完全弄清,可能与宫腔内灌注一定浓度hCG后,其能以旁分泌形式作用于子宫内膜上皮细胞和血管内皮细胞等的表面受体而发挥作用,进而促使母-胎界面血管形成、增强母-胎间的免疫耐受有关;还可能与延长子宫内膜的移植窗,使子宫内膜容受性增强有关。 Human chorionic gonadotropin (hCG), a glycoprotein hormone synthesized by placental syncytiotrophoblasts, has the functions of maintaining the luteal life span, stimulating the synthesis of estrogen and progesterone, inhibiting the proliferation of lymphocytes by phytohemagglutinin Features. Recent studies have shown that intrauterine implantation of hCG before embryo transfer can significantly improve the implantation rate and pregnancy rate after transplantation, but its specific mechanism of action has not yet been fully understood, and may be intrauterine perfusion with a certain concentration of hCG, its ability to paracrine Form on the endometrial epithelial cells and vascular endothelial cells and other surface receptors and play a role, and then to promote the formation of maternal and fetal blood vessels at the interface, to enhance the immune response of the mother-fetus; may also be related to the extension of endometrial transplantation Window, so that endometrial receptivity increased.