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目的 :探讨了肝病患者血清IGF -Ⅱ水平及临床意义。方法 :采用放射免疫分析 118例肝病患者血清中IGF -Ⅱ和HA、PⅢP含量 ,并与 30名正常人作比较。结果 :肝病患者血清中IGF水平非常显著地高于正常人组(P <0 0 1) ,尤以肝癌组为甚。且与HA、PⅢP呈明显的正相关。结论 :血清中IGF -Ⅱ测定有助于肝癌和肝硬化患者的病情观察和预后判断 ,具有一定的临床价值。
Objective: To investigate the serum level of IGF-Ⅱ in patients with liver disease and its clinical significance. Methods: The levels of IGF-Ⅱ, HA and PⅢP in serum of 118 patients with liver disease were analyzed by radioimmunoassay, and compared with 30 normal subjects. Results: Serum IGF levels in patients with liver disease were significantly higher than those in normal controls (P <0.01), especially in HCC patients. And with HA, P Ⅲ P showed a significant positive correlation. Conclusion: Serum IGF-Ⅱ is helpful to the observation and prognosis of patients with liver cancer and cirrhosis, and has certain clinical value.