目的 :本文总结原发性肾病综合征继发急性肾功能衰竭的临床与病理。　方法 :收集我科 1991年 1月至1998年 7月 NS继发 ARF的住院患儿。　结果 :NS继发 ARF的患儿发生率为 3.9% ,临床上以少尿型为主( 75 % ) ,多数发生在 NS发病后 3个月内 ,起病均在 NS的急性期 ,发生 ARF前常常以感染作为诱因 ,经肾活检证实病理类型以 Ms PGN与 MCN最为多见 (二者占 82 .15 % )。　结论 :明确 NS继发 ARF,需尽早给予合适的或联合治疗 ,大多数病儿 ARF是可以逆转的 Objective: This article summarizes the clinical and pathological features of primary nephrotic syndrome secondary to acute renal failure. Methods: We collected hospitalized children with NS secondary ARF from January 1991 to July 1998 in our department. Results: The incidence of NSF secondary to ARF was 3.9%. Oliguria was the mainstay in clinical practice (75%), most of which occurred within 3 months after onset of NS. The onset was all in the acute stage of NS with ARF Infection was often used as a predisposition, by the renal biopsy confirmed the pathological type Ms PGN and MCN most common (both accounted for 82.15%). Conclusions: It is necessary to give appropriate or combined treatment as soon as possible after definite NS secondary ARF. ARF in most children can be reversed