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这是近年出现的一类新型降压药,主要作用肾素—血管紧张素——醛固酮系统(Renin—Anqiotensin—Aldoste-rone System),即 RAA 系统。血浆中肾素(Renin)增多,能引起血压升高已被肯定。原因肾素分泌增多,活性增强,使全身小动脉血管收缩,外周阻力增大的结果。肾素是肾小球近球细胞分泌的一种蛋白水解酶,能催化血浆中的α_2—球蛋白,即血管紧张素原,生成血管紧张素I,(AnqiotesisI),这是一十肽物质。血管紧张素I,简写 AI,缩血管作用很弱,但随血液流经肺部小血管时,在血管紧张素转化酶(ACE)作用下,再次脱
This is a new type of antihypertensive drugs in recent years, the main role of the renin-angiotensin-aldosterone system (Renin-Anqiotensin-Aldostereone System), the RAA system. Increased plasma Renin, can cause elevated blood pressure has been confirmed. Reasons for increased renin secretion, increased activity, so that systemic arteriolar vasoconstriction, increased peripheral resistance as a result. Renin is a proteolytic enzyme secreted by glomerular near-globus cells and catalyzes the alpha-2-globulin, angiotensinogen, in the plasma to produce angiotensin I (Anqiotesis I), a ten-peptide substance. Angiotensin I, abbreviated as AI, has a weak vasoconstrictor effect. However, with the flow of blood through the small blood vessels in the lungs, under the action of angiotensin-converting enzyme (ACE), angiotensin I