1前言含吡啶杂环的中间体化学性质非常活泼,在抗生素、香料、农用杀虫剂、杀菌剂和除草剂领域应用十分广泛。2-羟基-6-三氟甲基烟腈是合成高效除草剂氟啶嘧磺隆的重要中间体。氟啶嘧磺隆是美国杜邦公司开发的磺酰脲类除草剂。其对许多一年生或多年生阔叶杂草有很好的效果,广泛应用于小麦作物田、稻田、大豆田、玉米田,只需极低剂量(约2~75g/hm2)。磺酰脲类除草剂活性为常见除草剂的 1 Introduction Pyridine heterocyclic intermediates very active chemical properties in the antibiotics, spices, agricultural insecticides, fungicides and herbicides in a wide range of applications. 2-hydroxy-6-trifluoromethylnicotinonitrile is an important intermediate for synthesizing fluoxasulfuron. Phyzosulfuron is a sulfonylurea herbicide developed by DuPont. It has good effect on many annual or perennial broadleaf weeds and is widely used in wheat crop fields, paddy fields, soybean fields and corn fields with very low dosage (about 2 ~ 75g / hm2). Sulfonylurea herbicides are common herbicides