热休克蛋白是受高温等刺激所诱导产生的一组应激蛋白。多种原因所造成的神经元过度兴奋均能诱导其在脑内表达，且与神经元的兴奋性损伤密切相关，被认为对神经元具有保护作用。对热休克蛋白的生物学特性、其在神经元过度兴奋后脑内不同部位的表达及影响因素和表达的意义的研究已取得进展。 Heat shock protein is stimulated by high temperature induced a set of stress proteins. A variety of reasons caused by neuronal over-excitement can be induced in the brain expression, and is closely related to the excitotoxicity of neurons, is considered to have a protective effect on neurons. The biological characteristics of heat shock protein, its neuronal hyperactivity in different parts of the brain after the expression and the impact of factors and the significance of the study has made progress.