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目的分析慢性乙型肝炎患者HBeAg、PreS1-Ag与HBV-DNA的相关性,探讨PreS1-Ag检测在监测慢性乙型肝炎患者病毒复制中的临床意义。方法 170例慢性乙型肝炎患者均采用酶联免疫吸附法(ELISA)检测HBV-M及PreS1-Ag,实时荧光定量聚合酶链反应(FQ-PCR)检测HBV-DNA。结果 170例慢性乙型肝炎患者中HBeAg阳性率为24.1%(41/170),PreS1-Ag阳性率为61.7%(105/170),两者阳性率具有显著的统计学差异(χ2=39.38,P<0.005),110例“小三阳”患者中PreS1-Ag阳性率达58.2%(64/110)。结论 PreS1-Ag与HBV-DNA的相关性明显优于HBeAg,是慢乙肝患者病毒复制的良好监测指标。
Objective To analyze the correlation between HBeAg, PreS1-Ag and HBV-DNA in patients with chronic hepatitis B and to explore the clinical significance of PreS1-Ag in monitoring viral replication in patients with chronic hepatitis B. Methods HBV-M and PreS1-Ag were detected by enzyme-linked immunosorbent assay (ELISA) and HBV-DNA by real-time fluorescence quantitative polymerase chain reaction (FQ-PCR) in 170 chronic hepatitis B patients. Results The positive rate of HBeAg in 170 patients with chronic hepatitis B was 24.1% (41/170) and the positive rate of PreS1-Ag was 61.7% (105/170). The positive rates of HBeAg were statistically significant (χ2 = 39.38, P <0.005). PreS1-Ag positive rate was 58.2% (64/110) in 110 cases of “Small Sanyang”. Conclusion The correlation between PreS1-Ag and HBV-DNA is better than that of HBeAg, which is a good indicator of virus replication in chronic hepatitis B patients.