胆管癌是起源于胆管系统上皮细胞的恶性肿瘤,在肝脏原发性肿瘤中,胆管癌的发病率仅次于肝癌[1,2]。近年来,胆管癌已经成为肝内原发肿瘤导致死亡的第一位[1,3]。发病率的升高可能与丙型肝炎病毒感染率的升高及其长期引起的慢性胆管炎症状态有关[4]。目前认为,胆管癌的发生发展是 Cholangiocarcinoma is a malignant tumor that originates from the epithelial cells of the biliary tract. In primary liver tumors, the incidence of cholangiocarcinoma is second only to that of liver cancer [1,2]. In recent years, cholangiocarcinoma has become the leading cause of primary liver cancer death [1,3]. The increased incidence may be associated with an increased hepatitis C virus infection and its long-term status of chronic cholangitis caused by inflammation [4]. At present, the occurrence and development of cholangiocarcinoma is