目的：观察国产培洛霉素治疗非小细胞肺癌的疗效。方法：用国产与进口培洛霉素进行临床对照观察。结果：国产培洛霉素单药治疗组有效率为３３．３％，高于国外报道（１１．８％）。联合化疗组（国产培洛霉素）与对照组（进口培洛霉素）疗效分别为５３．３％与５０．０％，二组无显著性差异。结论：国产药与进口药疗效相似，且毒副反应较小，是一种疗效较好的抗肿瘤新药，可用于治疗非小细胞肺癌 Objective: To observe the efficacy of domestic pelothycin in the treatment of non-small cell lung cancer. Methods: Clinical control of domestic and imported Pelowaycin was performed. RESULTS: The effective rate of domestic pelolimine monotherapy group was 33.3%, which was higher than that reported abroad (11.8%). The efficacy of the combined chemotherapy group (made pelothilomycin) and the control group (imported pelarcin) was 53.3% and 50.0%, respectively, and there was no significant difference between the two groups. Conclusion: The efficacy of domestic and imported drugs is similar, and the side effects are minor. It is a new antitumor drug with good curative effect and can be used for the treatment of non-small cell lung cancer.