特发性浮肿是临床上具有一定特征的原因不明浮肿。其产生不是由于心、肾、肝疾患,甲状腺功能减退,直立性低血压,潴钠药物,变态反应性疾病,低蛋白血症,静脉或淋巴管病症等已知疾病或基础病变,病因未明。一、病因及病理生理本病病因可能与多种因素有关。以下为一些假说。(一)直立时循环血量减少: 本病浮肿特征为立位时浮肿增加,尿钠排出减少,其原因可能是由于直立时血浆成分向血管外渗出增加及血液潴留于身体下垂部位而使循环血量减少。此外,还可能同以下局部因素有关。1.毛细血管通透性增加:许多病例有糖尿病的遗传素质、糖代谢异常,腓肠肌活检可见与糖尿病微 Idiopathic edema is clinically certain characteristics of unexplained edema. Its cause is not due to heart, kidney, liver disease, hypothyroidism, orthostatic hypotension, sodium retention drugs, allergic diseases, hypoproteinemia, venous or lymphatic disorders and other known diseases or underlying diseases, the etiology is unknown. First, the etiology and pathophysiology The etiology of the disease may be related to many factors. Here are some hypotheses. (A) reduce the blood flow when erected: The edema characteristics of this disease increased edema when standing position, reduced urinary sodium excretion, the reason may be due to the vertical rise of plasma components to extravascular extravasation and blood retention in the body parts of the sag Circulation of blood reduced. In addition, it may be related to the following local factors. 1. Capillary permeability increased: many cases of genetic quality of diabetes, abnormal glucose metabolism, gastrocnemius muscle biopsy can be seen with the micro-diabetes