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1例52岁男性患者为保健口服自行购买的益脑宁片（3片/次，3次/d）。服药第18天患者出现全身皮肤及巩膜黄染、尿液变黄，第24天出现乏力、纳差。实验室检查示丙氨酸转氨酶（ALT）1 132 U/L，天冬氨酸转氨酶（AST）953 U/L，总胆红素（TBil）80.0 μmol/L，直接胆红素（DBil）73.4 μmol/L，碱性磷酸酶（ALP）203 U/L，γ-谷氨酰转移酶（γ-GT）155 U/L。考虑为益脑宁片引起的急性肝损伤。停用该药并给予保肝及退黄治疗。停药第8天，ALT 192 U/L，AST 158 U/L，TBil 51.0 μmol/L，DBil 39.9 μmol/L，ALP 178 U/L, γ-GT 149 U/L，患者食欲恢复，皮肤及巩膜黄染明显好转。停药第13天，患者皮肤、巩膜黄染消除，ALT 56 U/L，AST 62 U/L，TBil 30.7 μmol/L，DBil 22.4 μmol/L，ALP 164 U/L，γ-GT 142 U/L。随访6个月，患者肝功能未见异常。“,”A 52-year-old male patient received self-purchased n Yinaoning tablets (益脑宁片) (3 tablets, trice daily) orally for health care. On day 18 of medication, the patient developed jaundiced skin and sclera and dark urine. On day 24, he developed fatigue and anorexia. Laboratory tests showed alanine aminotransferase (ALT) 1 132 U/L, aspartate aminotransferase (AST) 953 U/L, total bilirubin (TBil) 80.0 μmol/L, direct bilirubin (DBil) 73.4 μmol/L, alkaline phosphatase (ALP) 203 U/L, and gamma-glutamyltransferase (γ-GT) 155 U/L. Acute liver injury induced by n Yinanning tablets was considered. Then the drug was discontinued and liver-protective therapy and drugs for anti-jaundice were given. On day 6 of drug withdrawal, the laboratory tests showed ALT 192 U/L, AST 158 U/L, TBil 51.0 μmol/L, DBil 39.9 μmol/L, ALP 178 U/L, and γ-GT 149 U/L, his appetite recovered, and the yellowish skin and sclera improved markedly. On day 13 of drug withdrawal, his yellowish skin and sclera disappeared, and the laboratory tests showed ALT 56 U/L, AST 62 U/L, TBil 30.7 μmol/L, DBil 22.4 μmol/L, ALP 164 U/L, and γ-GT 142 U/L. At 6 months of follow-up, there were no abnormalities in his liver function.n