使用预防性抗生素以前,阑尾切除术后感染的发生率大约30％。后来认识到无芽孢厌氧菌对阑尾术后切口感染具有重要意义,继而介绍了甲硝哒唑(MTZ)有特异性预防作用。嗣后很多报告以单剂MTZ静脉用药或持续7天直肠给药有效的预防阑尾术后切口感染。这种方法在英国已逾越95％的外科医生使用。然而,近来文献报告使用MTZ预防阑尾术后切口感染的病例中有15～20％病例发生需氧菌感染,因而对其单一使用提出异 Before using prophylactic antibiotics, the incidence of appendectomy infection was about 30%. Later realized that non-spore anaerobes incision infection after appendix is ​​of great significance, and then introduced metronidazole (MTZ) has a specific preventive effect. Subsequent reports of numerous single doses of MTZ intravenous drug or rectal administration for 7 days effective in preventing incision infection after appendix. This method has been used by more than 95% of surgeons in the UK. However, recent literature reports that using MTZ to prevent appendix incision infection in 15% of cases occurred in 20% of cases of aerobic infections, so its single use were made different