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目的探讨腹腔镜胃癌手术与开腹胃癌手术对胃癌组织黏附分子CD44V6和ICAM-1表达的影响。方法应用免疫组化两步法,对比福建省肿瘤医院2008-2010年经开腹手术治疗的81例胃癌标本,与同期腹腔镜手术治疗的55例胃癌标本黏附分子CD44V6和ICAM-1的表达情况。结果通过比较开腹组与腹腔镜组胃癌标本黏附分子CD44V6和ICAM-1蛋白表达情况,发现腹腔镜组CD44V6和ICAM-1蛋白表达均低于开腹组,差异有统计学意义(P<0.05或P<0.01)。结论腹腔镜手术的CO_2气腹对胃癌黏附分子的表达可能有抑制作用,腹腔镜手术可能不增加胃癌患者其他器官转移风险,可能对胃癌转移有一定的抑制作用。
Objective To investigate the effect of laparoscopic gastric surgery and open gastric cancer surgery on the expression of adhesion molecules CD44V6 and ICAM-1 in gastric cancer. Methods The immunohistochemical two-step method was used to compare the expression of CD44V6 and ICAM-1 in 81 gastric cancer specimens from 2008 to 2010 in Fujian Tumor Hospital from 2008 to 2010 and 55 gastric cancer specimens during the same period of laparoscopic surgery . Results The expression of CD44V6 and ICAM-1 in laparoscopic group was significantly lower than that in laparoscopic group (P <0.05) Or P <0.01). Conclusions Pneumoperitoneum of laparoscopic surgery may inhibit the expression of adhesion molecules in gastric cancer. Laparoscopic surgery may not increase the risk of metastasis of other organs in gastric cancer, and may have some inhibitory effects on gastric cancer metastasis.