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目的分析脊髓灰质炎(脊灰)病毒(PV)的急性弛缓性麻痹(AFP)病例流行病学特征,以增加AFP病例监测系统敏感性。方法对西安市2008年AFP病例进行流行病学分析。结果西安市2008年AFP病例监测系统共报告AFP23例,确诊非脊灰AFP病例22例,15岁以下儿童非脊灰报告发病率2.12/10万。采集标本21例,合格标本20例,合格标本采集率90.90%,标本分离出PVⅡ型株1株,型内特征鉴定为疫苗变异PV,经病毒蛋白1(VPl)基因核苷酸序列测定未达到疫苗衍生脊灰病毒(VDPV)的分类标准。非脊灰肠道病毒(NPEV)3株,NPEV分离率14.29%。其他各项监测指标均达到世界卫生组织(WHO)要求。结论要维持该市无脊灰状态,应继续保持高质量的AFP病例监测系统,保证高水平的脊灰减毒活疫苗(OPV)接种率。
Objective To analyze the epidemiological characteristics of acute flaccid paralysis (AFP) cases of poliomyelitis (PV) in order to increase the sensitivity of AFP surveillance system. Methods The epidemiological analysis of AFP cases in Xi’an in 2008 was conducted. Results AFP case surveillance system in Xi’an in 2008 reported a total of 23 cases of AFP, non-polio AFP cases were confirmed in 22 cases, children under 15 years of age reported a non-polio incidence of 2.12 / 100000. Twenty-one specimens were collected, 20 specimens were qualified and 90.90% specimens were collected. One strain of PVⅡ was isolated from the specimen, and the type of vaccine was identified as the vaccine variant PV. The nucleotide sequence of the VP1 gene was not detected Vaccine derived poliovirus (VDPV) classification criteria. Three strains of non-polio enterovirus (NPEV), NPEV isolation rate of 14.29%. Other monitoring indicators have reached the World Health Organization (WHO) requirements. Conclusion To maintain a polio-free status in the city, high-quality AFP case monitoring systems should be maintained to ensure high levels of live attenuated poliovirus (OPV) vaccination.