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本文总结了近年对RPGN治疗方法及其临床应用原则等方面的研究进展。RPGN早期治疗特别重要 ,Ⅰ型除了常规使用血浆置换及免疫抑制剂外 ,还可使用Deoxyspergualin、白介素 1受体拮抗剂、抗细胞间粘附分子 1及淋巴细胞功能相关抗原 1单克隆抗体、抗巨噬细胞移动抑制因子抗体等 ;Ⅱ型主要选用激素冲击 ;Ⅲ型则强调早期使用激素及免疫抑制剂 ,长期大剂量使用白介素和干扰素对本型RPGN可能有诱发作用
This article summarizes the research progress of RPGN treatment and its clinical application in recent years. Early treatment of RPGN is particularly important, type I in addition to conventional use of plasma exchange and immunosuppressive agents, but also the use of Deoxyspergualin, interleukin 1 receptor antagonist, anti-cell adhesion molecule 1 and lymphocyte function-associated antigen 1 monoclonal antibody, anti Macrophage migration inhibitory factor antibodies; type Ⅱ mainly used hormonal impact; type Ⅲ emphasizes the early use of hormones and immunosuppressive agents, long-term high-dose use of interleukin and interferon on this type of RPGN may be induced