对半合成紫杉醇类化合物的关键步骤 １０－去乙酰基巴卡亭 Ⅲ（１０－ＤＡＢ）的羟基保护反应进行了研究。结果表明，利用氯甲酸（２，２，２－三氯）乙酯作为羟基保护基，获得７。１０－二（三氯乙氧基）－１０一去乙酰基巴卡亭Ⅲ［７，１０－ｄｉ（Ｔｒｏｃ）－１０－ＤＡＢ］的反应为连串反应，受反应时间和温度影响较大。当反应温度为 ８０℃，反应时间为 ２ ｍｉｎ时，目的产物 ７，１０－ｄｉ（Ｔｒｏｃ）－１０－ＤＡＢ的反应选择性最好。 Hydroxylation of 10-deacetylbaccatin III (10-DAB), the key step of semisynthetic paclitaxel, was investigated. The results showed that 7.10-bis (trichloroethoxy) -10-deacetylbaccatin III [7, 10 -di (Troc) -10-DAB] is a series of reactions, which are greatly affected by reaction time and temperature. When the reaction temperature was 80 ℃ and the reaction time was 2 min, the reaction product of 7,10-di (Troc) -10-DAB was the best.