论文部分内容阅读
目的 探讨褪黑激素和血清素对鼠胃酒精性溃疡形成及黏膜血流的影响。方法 制备胃在体动物模型。分别皮下注入血清素及同容积生理盐水。用褪黑激素及同容积蒸馏水作为浸育液分别放入各组鼠的胃腔中。 30min末测毕胃黏膜血流后 ,采用 40 %的酒精作为浸育液分别放入各组鼠胃腔中 ,继续检测胃黏膜血流并测量胃黏膜损伤指数。结果 褪黑激素和血清素两者均不能损伤鼠胃黏膜 ,但血清素可降低胃黏膜血流 ,且与其剂量相关。褪黑激素可减轻由酒精引起的胃黏膜损伤和胃黏膜血流减少 ,而血清素可加重酒精引起的胃黏膜损伤和胃黏膜血流减少 ,但可被褪黑激素部分逆转。结论 胃黏膜的损伤与胃黏膜血流有关 ,但不是溃疡形成的唯一因素。因此 ,能拮抗血清素的褪黑激素可作为在胃肠道作用的调节剂
Objective To investigate the effects of melatonin and serotonin on alcoholic gastric ulcer formation and mucosal blood flow in rats. Methods Gastric in vivo animal models were prepared. Subcutaneous injection of serotonin and the same volume of saline. With melatonin and the same volume of distilled water as immersion liquid were placed in the rat stomach. 30min after the end of gastric mucosal blood flow, the use of 40% alcohol as immersion liquid were placed in the stomach of rats, and continue to detect gastric mucosal blood flow and gastric mucosal injury index. Results Both melatonin and serotonin did not impair gastric mucosa in mice, but serotonin decreased gastric mucosal blood flow and was dose dependent. Melatonin can reduce gastric mucosal injury and gastric mucosal blood flow reduction caused by alcohol, while serotonin can aggravate alcohol-induced gastric mucosal injury and gastric mucosal blood flow, but can be partially reversed by melatonin. Conclusion The gastric mucosal injury is related to gastric mucosal blood flow, but not the only factor of ulcer formation. Therefore, melatonin, which antagonizes serotonin, can serve as a regulator of gastrointestinal effects