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异名 Rosal 化学名 9-羟基-19,20-二去甲前列腺烷酸钠盐药效分类抗溃疡药开发单位 (意大利)Istituto Biochimico Italiano Giovanni Lorenzini S.P.A. 上市厂商 (意大利)Istituto Biochiinico Italiano Giovanni Lorenzini S.P.A.1985年9月首次上市合成以蓖麻油酸为起始原料,与醋酸汞、钠硼氢反应得9,12-二羟基十八烷酸,后者经CrO_3氧化得9,12-二氧十八烷酸,继而用H_2SO_4在回流的甲醇-水中环合得9-氧-19,20-二去甲-8(12)-前列腺烯酸,后者经PtO_2催化氢化双键,最后用NaBH_4还原9-
Synonyms Rosal Chemical Name 9-Hydroxy-19,20-Di-norepinephrine Sodium salt Pharmacodynamic Category Anti-ulcer drug development unit (Italy) Istituto Biochimico Italiano Giovanni Lorenzini SPA Listed Company (Italy) Istituto Biochiinico Italiano Giovanni Lorenzini SPA1985 The first listing in September of the synthesis of ricinoleic acid as the starting material, with mercury acetate, sodium borohydride reaction 9,12-dihydroxy octadecanoic acid, which was CrO_3 oxidation 9,12-dioxooctadecane Acid, followed by cyclization of 9-oxo-19,20-dideoxy-8 (12) -epynoic acid with H 2 SO 4 in refluxing methanol-water, which catalyzed hydrogenation of double bonds by PtO 2 and reduction of 9-