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目的 研究过氧化物酶体增殖因子活化受体γ(PPARγ)和维甲酸受体α(RXRα)在慢性胃炎、胃黏膜不典型增生及胃癌组织中的表达 ,探讨PPARγ和RXRα在该演进序列中的意义及相关性。方法 采用ABC免疫组化法 ,检测 5 3例胃癌手术标本中PPARγ和RXRα的表达 ,同时随机选取 18例胃黏膜不典型增生、31例慢性非萎缩性胃炎及 30例慢性萎缩性胃炎作对照研究。结果 PPARγ和RXRα于胃癌中的表达率为 41.5 %和 5 4.7% ,在胃黏膜不典型增生为 2 7.8%和 38.9% ,慢性萎缩性胃炎中为 10 .0 %和 2 0 .0 % ,慢性非萎缩性胃炎中为 6 .5 %和 16 .1% ;从慢性胃炎、胃黏膜不典型增生到胃癌 ,PPARγ和RXRα阳性率呈递增趋势 ;与慢性胃炎相比 ,胃黏膜不典型增生及胃癌中PPARγ和RXRα的表达率均显著升高 (P <0 .0 5 ,P <0 .0 1) ;PPARγ和RXRα表达与胃癌有无淋巴结转移及胃癌的分化程度无相关性 (P >0 .0 5 ) ;胃癌中PPARγ和RXRα的表达呈显著正相关 (r =0 .5 4)。结论 PPARγ和RXRα于胃癌及胃癌前病变中表达上调 ,可能是胃癌发生过程中的早期事件。
Objective To investigate the expression of peroxisome proliferator-activated receptor γ (PPARγ) and retinoic acid receptor α (RXRα) in chronic gastritis, dysplasia of gastric mucosa and gastric cancer, and to explore the role of PPARγ and RXRα in this evolutionary sequence. The significance and relevance. Methods ABC immunohistochemical method was used to detect the expression of PPARγ and RXRα in 53 specimens of gastric cancer. Randomly selected 18 cases of gastric dysplasia, 31 cases of chronic non-atrophic gastritis and 30 cases of chronic atrophic gastritis were used as controls. . Results The expression rates of PPARγ and RXRα in gastric cancer were 41.5% and 5 4.7%, gastric dysplasia was 27.8% and 38.9%, and chronic atrophic gastritis was 10.0% and 20.0%. 65% and 16.1% of non-atrophic gastritis; from chronic gastritis, gastric dysplasia to gastric cancer, the positive rate of PPARγ and RXRα increased; compared with chronic gastritis, gastric dysplasia and gastric cancer The expression rates of PPARγ and RXRα were significantly increased (P <0.05, P <0.01). The expression of PPARγ and RXRα did not correlate with lymph node metastasis and the differentiation of gastric cancer (P>0. The expression of PPARγ and RXRα in gastric cancer was significantly positively correlated (r = 0.54). Conclusion The expression of PPARγ and RXRα in gastric cancer and precancerous lesions is up-regulated and may be an early event in the development of gastric cancer.