目的：探讨米非司酮配伍不同剂量、不同给药方法的前列腺素类终止孕１０～１６周妊娠的临床效果。方法：减少前列腺素类的剂量及延长给药间隔。分三组，Ａ组：米非司酮，首次５０ｍｇ，以后每１２小时口服２５ｍｇ，共４次，总剂量１５０ｍｇ；第３天晨口服米索前列醇０６ｍｇ，必要时６小时后再服一次。Ｂ组：米非司酮用法同Ａ组，第３天晨阴道放置卡孕栓１ｍｇ，必要时６小时后再放置１枚。Ｃ组：米非司酮，同上；第３天晨口服米索前列醇０４ｍｇ，每４小时１次，共３次。结果：三组有效流产率分别为９５３％、９２２％和８７５％，无显著性差异（Ｐ＞００５），前列腺素平均用量分别为０８７±０３ｍｇ、１４２±０５ｍｇ和０８６±０４ｍｇ，Ｂ组明显高于Ａ、Ｃ组，有非常显著性差异（Ｐ＜００１）。副反应发生率分别为２５０％、４６９％和１７２％，Ｂ组高于Ａ、Ｃ组（Ｐ＜００１）。结论：三种方案终止孕１０～１６周妊娠均获较好效果；Ａ组方案，有效率达９５２％，完全流产率高于Ｂ、Ｃ组，副反应轻，前列腺素用量少，值得推广。 OBJECTIVE: To investigate the clinical effect of mifepristone with different dosage and different administration methods of prostaglandins for termination of pregnancy of 10-16 weeks. Methods: Reduce the dose of prostaglandins and extend the interval between administrations. Divided into three groups, Group A: mifepristone, the first 50mg, after every 12 hours orally 25mg, a total of 4 times the total dose of 150mg; the first 3 days morning oral misoprostol 0 6mg, if necessary, 6 hours after the service once. Group B: mifepristone use the same group A, the first 3 days of morning vaginal placenta suppository 1mg, if necessary, place an additional 6 hours later. Group C: mifepristone, ibid. On the third day morning, misoprostol 0.4 mg was administered orally every three hours for 3 times. Results: The effective abortion rates of the three groups were 953%, 922% and 875% respectively, with no significant difference (P> 0.05). The average prostaglandin levels were 087 ± 03mg, 142 ± 05mg and 086 ± 04mg respectively. There was a significant difference between group B and group A (P <001). The incidence of side effects were 250%, 469% and 172%, respectively, while those in group B were higher than those in groups A and C (P <001). Conclusions: All the three regimens have good results in 10 to 16 weeks of gestation. In group A, the effective rate is 952%, and the rate of complete abortion is higher than that in groups B and C, with less side effects, less prostaglandin, Worth promoting.