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目的观察并分析原发性肾病综合征(primary nephritic syndrome,PNS)患者甲状腺素水平变化。方法 PNS患者68例(PNS组)、治疗后临床缓解PNS患者29例(缓解期组)、体检健康者35例(对照组),检测3组T3、T4、促甲状腺激素(thyroid-stimulating hormone,TSH)、血清白蛋白及尿蛋白等水平并进行组间比较。结果 PNS组与对照组血清T3、T4比较差异有统计学意义(P<0.01),而TSH比较差异无统计学意义(P>0.05);缓解期组与PNS组T3、T4比较差异有统计学意义(P<0.01),2组TSH比较差异无统计学意义(P>0.05);PNS患者治疗前血清T3、T4与血清白蛋白呈正相关(r=0.95,P<0.01;r=0.76,P<0.01),与尿蛋白呈负相关(r=-0.53,P<0.05;r=-0.76,P<0.01)。结论 PNS患者血清甲状腺素水平下降与尿液中丢失大量蛋白有关,且甲状腺素减低程度与PNS病情相关。
Objective To observe and analyze the changes of thyroid hormone in patients with primary nephritic syndrome (PNS). Methods Sixty-eight patients with PNS (PNS group), 29 patients with PNS (remission group), 35 healthy subjects (control group), 3 groups of T3 and T4 thyroid-stimulating hormone TSH), serum albumin and urinary protein levels and compared between groups. Results There were significant differences in serum T3 and T4 between PNS group and control group (P <0.01), but there was no significant difference in TSH between PNS group and control group (P> 0.05). T3 and T4 in remission group and PNS group were statistically different (P <0.01). There was no significant difference in TSH between the two groups (P> 0.05). Serum albumin was positively correlated with T3 and T4 before treatment in PNS patients (r = 0.95, P <0.01; <0.01), but negatively correlated with urinary protein (r = -0.53, P <0.05; r = -0.76, P <0.01). Conclusions The decrease of serum thyroxine level in patients with PNS is related to the loss of a large amount of protein in urine. The degree of thyroxine reduction is correlated with the severity of PNS.