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A series of neamine-heterocycle conjugates were designed and synthesized.All new compounds displayed more potent inhibitory effect on HIV replication than neamine,among them two compounds displayed stronger anti-HIV activity than neomycin B.The results suggested that it might be a promising approach to modify neamine for the discovery of new anti-HIV agents.
A series of neamine-heterocycle conjugates were designed and synthesized. All new compounds displayed more potent inhibitory effect on HIV replication than neamine, among them two compounds showed stronger anti-HIV activity than neomycin B. The results suggest that it might be a promising approach to modify neamine for the discovery of new anti-HIV agents.