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目的：探讨贲门癌细胞生物学行为及其临床意义。方法：应用Ｓ－Ｐ免疫组织化学方法，应用Ｖｉｍ、ＣＨＧ、ＨＣＧ３种抗体对６２例贲门癌进行标记。结果：ＣＨＧ抗体表达１２例，ＨＣＧ表达３２例，Ｖｉｍ表达３３例，ＣＨＧ－Ｖｉｍ共同表达１２例，ＨＣＧ－Ｖｉｍ共同表达１９例，ＣＨＧ－ＨＣＧ共同表达９例，ＨＣＧ－Ｖｉｍ－ＣＨＧ共同表达８例。其中Ｖｉｍ、ＨＣＧ表达的肿瘤６０％以上出现在低分化癌细胞中。结论：贲门癌具有多向分化的特征，伴有向间叶、滋养叶分化的肿瘤大多数分化低并与临床预后有一定关系。对认识贲门癌生物学行为，探讨其预后及依肿瘤向不同组织分化采用药物治疗有指导意义。
Objective: To investigate the biological behavior and clinical significance of cardiac cancer cells. Methods: Using S-P immunohistochemistry method, Vim, CHG and HCG antibodies were used to label 62 cases of cardiac cancer. RESULTS: There were 12 cases of CHG antibody expression, 32 cases of HCG expression, 33 cases of Vim expression, 12 cases of CHG-Vim co-expression, 19 cases of HCG-Vim co-expression, 9 cases of CHG-HCG co-expression, and 8 cases of HCG-Vim-CHG co-expression. example. Among them, more than 60% of the tumors expressed by Vim and HCG appeared in poorly differentiated cancer cells. Conclusion: Cardia adenocarcinoma is characterized by multi-differentiation, and most of the tumors with mesenchymal and trophoblastic differentiation have low differentiation and have a certain relationship with clinical prognosis. To understand the biological behavior of cardiac cancer, to explore its prognosis and to guide the differentiation of tumors to different tissues using drug therapy.