通过检测Ⅷ因子活性、Ⅸ因子活性和Ⅷ因子相关抗原,诊断血友病81例,血友病甲∶血友病乙∶血友病丙∶其它为4.6∶1∶0.3∶0.3;其中男78例,女3例。32例有家族史。12岁以下发病的74例。发生出血的最小年龄为出生后第2天。出血的主要部位是皮肤和粘膜,其次是关节。根据Ⅷ因子活性、Ⅸ因子活性的浓度分型:重型75.4%,中间型16.4%,轻型8.2%。 Hemophilia A was diagnosed in 81 cases by detecting the activity of factor Ⅷ, activity of factor Ⅸ and antigen associated with factor Ⅷ, hemophilia A: hemophilia B: hemophilia C: others were 4.6: 1: 0.3: 0.3, of which male 78 Cases, female 3 cases. 32 cases had a family history. 74 cases of onset under the age of 12. The minimum age for bleeding is 2 days after birth. The main site of bleeding is the skin and mucous membranes, followed by the joints. According to the activity of factor Ⅷ, the activity of factor Ⅸ concentration type: heavy 75.4%, intermediate 16.4%, light 8.2%.