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目的 评价舒噻嗪治疗癫痫强直 -阵挛发作 (GTCS)的疗效和安全性。方法 对 146例 GTCS患者采取随机分组、开放试验、苯妥英钠对照多中心的临床研究。其中舒噻嗪研究组 32例 ,开放组 82例 ,苯妥英钠对照组 32例。结果 舒噻嗪研究组对 GTCS总有效率 90 .6 % ,苯妥英钠对照组总有效率 81.3% ,两组间无显著差别 (P>0 .0 5 ) ;舒噻嗪对患者血常规、肝肾功能、心电图均无明显影响 ;舒噻嗪引起的不良反应发生率为 2 6 .3% ,苯妥英钠组为 2 5 .0 % ,两组相比无显著差异 (P>0 .0 5 ) ,舒噻嗪所致不良反应极大多数轻微且不需特别处理。结论 舒噻嗪是治疗 GTCS有效且较安全的一种药物
Objective To evaluate the efficacy and safety of Azothiazide in the treatment of epileptic tonic-clonic seizures (GTCS). Methods A total of 146 patients with GTCS were randomized, open-label and phenytoin control multicenter clinical study. Among them, 32 cases were in the study group of thiazide, 82 cases in the open group and 32 cases in the phenytoin control group. Results The total effective rate of GTCS was 90.6% in the study group and 81.3% in the phenytoin control group, with no significant difference between the two groups (P> 0.05) Renal function and electrocardiogram had no significant effect. The incidence of adverse reactions caused by sulthiazine was 26.3% and that of phenytoin sodium was 25.0%, there was no significant difference between the two groups (P> 0.05) , Most of the side effects caused by sulpiride were mild and did not require special treatment. Conclusion It is a safe and effective drug to treat GTCS