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目的探讨在临床上多次输血患者体内产生不规则抗体的情况及输血解决策略。方法回顾性分析2015年1月-2016年4月,本院住院患者中符合输血至少2次以上,且第1次输血前不规则抗体筛查为阴性,之后至少有1次输血前不规则抗体筛查阳性,并与库存至少20单位同型献血者血液交叉配血,部分或全部不相合的患者9名,并对此9名患者进行血型鉴定、不规则抗体筛查及进一步抗体鉴定等多种血型血清学试验,确定抗体类型并结合临床病史,给与适合血液输注。结果随着患者输血量和输血次数的增加,患者体内出现不规则抗体的机率增大、抗体类型也越为复杂,致使血型鉴定及交叉配血困难,寻找相合血液输注的机率越小。结论对有输血史及妊娠史的患者应常规进行不规则抗体筛查,及时发现有临床意义的抗体,确保临床用血及时、安全、有效。
Objective To investigate the situation of irregular antibodies produced in many blood transfusion patients in clinic and the strategy of blood transfusion. Methods Retrospective analysis from January 2015 to April 2016, hospital patients with blood transfusion at least 2 times, and the first irregular blood transfusion before screening was negative, then at least 1 before transfusion of irregular antibodies Screening positive and with at least 20 units of blood donors cross-type blood cross-partnered, in part or all of the nine patients do not match, and nine patients blood type identification, screening of irregular antibodies and further antibody identification and other Serological serological tests to determine the type of antibody combined with clinical history, to give appropriate blood transfusions. Results With the increase of blood transfusion and blood transfusion, the probability of irregular antibody in the patient increased and the type of antibody became more complicated. As a result, it was difficult to identify the blood type and cross the blood. Conclusion Patients with history of blood transfusion and pregnancy should be routinely screened for irregular antibodies, and timely detection of clinically meaningful antibodies to ensure clinical blood use is timely, safe and effective.