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[目的]探讨肝脏疾病时患者精氨酸代琥珀酸裂解酶(argininosuccinate lyase,ASL)的分泌及与肝病血清学指标的关系。[方法]102例明确诊断的肝病患者,测定血清ASL、甘氨酸胆酸(GCA)、丙氨酸氨基转移酶(ALT)和天冬氨酸转氨酶(AST),并与71例非肝病患者以及40例健康体检者(健康对照组)进行对照比较。[结果]肝病组血清ASL水平显著高于非肝病组和健康对照组(均P<0.01),而非肝病组和健康对照组间差异无统计学意义;GCA、ALT和AST 3组间差异均有统计学意义(均P<0.01)。受试者工作特征曲线(ROC Curve)显示ASL诊断肝脏疾病的诊断效率高于GCA、ALT和AST,相关性分析显示肝病患者血清ASL水平与GCA、ALT、AST呈正相关(均P<0.01)。[结论]ASL是反映肝脏疾病的灵敏指标,与常见的肝病血清学诊断指标有关联性,且诊断效率最高,适合临床开展肝病的鉴别诊断。
[Objective] To investigate the relationship between the secretion of argininosuccinate lyase (ASL) and the liver disease serological markers in patients with liver diseases. [Method] 102 patients with definite diagnosis of liver disease were measured serum ASL, glycine bile acid (GCA), alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and 71 patients with non-liver disease and 40 Cases of healthy subjects (healthy control group) for comparison. [Results] The serum ASL level in liver disease group was significantly higher than that in non-liver disease group and healthy control group (all P <0.01), but there was no significant difference between non-liver disease group and healthy control group. The differences among GCA, ALT and AST groups There was statistical significance (all P <0.01). ROC curve showed that the diagnostic efficiency of ASL in the diagnosis of liver disease was higher than that of GCA, ALT and AST. Correlation analysis showed that serum ASL level in patients with liver disease was positively correlated with GCA, ALT and AST (all P <0.01). [Conclusion] ASL is a sensitive indicator of liver disease. It is correlated with common diagnostic indicators of liver diseases and has the highest diagnostic efficiency. It is suitable for the differential diagnosis of liver diseases.