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目的:了解血清乙醇浓度与纳洛酮治疗量之间的相关性。方法:从我院2001年12月1日-2005年8月1日收治的共1991例急性乙醇中毒的病例中随机抽取181例,对这些病例的临床资料进行回顾性分析,了解血清乙醇浓度与纳洛酮治疗量、急性乙醇中毒的临床表现程度与纳洛酮治疗量之间的相关性。结果:变量两两间的相关分析表明:血清乙醇浓度与纳洛酮治疗量之间没有显著性意义的相关性(r=0.045,P>0.05)。而急性乙醇中毒的临床表现程度与纳洛酮治疗量之间有显著性意义的相关性(r=0.3,P<0.01)。结论:急性乙醇中毒的纳洛酮治疗剂量与中毒的临床表现程度有直接的相关性,而与血清乙醇浓度的相关性不显著。
Objective: To understand the correlation between serum ethanol concentration and naloxone treatment. Methods: A total of 181 cases were randomly selected from 1991 cases of acute alcoholism admitted from December 1, 2001 to August 1, 2005 in our hospital. The clinical data of these cases were retrospectively analyzed to understand the relationship between serum ethanol concentration and Naloxone treatment, the correlation between the clinical performance of acute alcoholism and the amount of naloxone treated. RESULTS: Correlation analysis between two variables showed no significant correlation between serum ethanol concentration and naloxone treatment (r = 0.045, P> 0.05). There was a significant correlation between the clinical manifestation of acute alcoholism and the dose of naloxone (r = 0.3, P <0.01). Conclusion: The dose of naloxone in acute alcoholism is directly related to the clinical manifestation of poisoning, but not to the serum ethanol concentration.