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皮质类固醇(下称激素)广泛治疗多种疾病已20余年,它减低了肾病、白血病、哮喘、类风湿关节炎等病的发病率与病死率;然而它的并发症变化多端,并发症可比原发疾病更为有害。本文回顾了小儿激素疗法的重要并发症。眼科并发症全身和局部激素疗法可发生严重和不可恢复的眼科并发症,如青光眼、白内障、眼部细菌和霉菌感染以及疱疹性角膜炎的加剧。用激素数日内即可产生眼内压增高,有青光眼家族史者更危险,原因为水分外流减少其发生与激素剂量有关,停药后眼内压复常。1960年Black等报告,白内障(后囊下)可发生于长期激素疗法之后。有人报告用激素治疗的肾病患儿有28%发生后囊下白内障,Fine报
Corticosteroids (hereinafter referred to as hormones) have been used extensively to treat a variety of diseases for more than 20 years, reducing the incidence and mortality of nephropathies, leukemias, asthma, rheumatoid arthritis and the like; however, its complications have varied and have comparable complications The disease is more harmful. This article reviews important complications of pediatric hormone therapy. Ophthalmic Complications Both systemic and topical hormone therapy can develop serious and irreversible ophthalmic complications such as glaucoma, cataracts, ocular bacterial and fungal infections, and an exacerbation of herpetic keratitis. Hormone intraday pressure can produce a few days with glaucoma family history of those who are more dangerous because of the reduction of water outflows and hormone dose related to withdrawal of intraocular pressure after IOP. 1960 Black et al. Reported that cataract (posterior subcapsular) can occur after long-term hormone therapy. Posterior capsular cataracts have been reported in 28% of children with steroid treated nephropathy, Fine reported