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目的随着近年肺结核发病的病例增多,耐药情况的普遍出现,尤其空洞型肺结核,临床治疗较难,易迁延不愈。为提高疗效,寻找更好的防治对策。方法采用IL-2联用SRHP方案1个月治疗空洞型肺结核25例,并以同期单用SRHP方案常规治疗作为参照(对照组)。用药后每半个月检查1次血常规、肝功能、血肌酐、胸片及痰菌检查并记录。观察空洞病灶愈合的程度和痰菌阴转率。结果治疗组患者的空洞病灶各有不同程度的愈合,痰找抗酸杆菌呈阴性,而对照组则空洞病灶无明显改变,痰菌阴转率较低。结论白细胞介素-2是一种效果显著的辅助性治疗空洞型肺结核的药物且安全可靠。
Objective With the increase of incidence of tuberculosis in recent years, the prevalence of drug resistance, especially empty tuberculosis, clinical treatment more difficult, easy to delay unhealed. In order to improve the curative effect, find a better control strategy. Methods Twenty-five patients with cavitary pulmonary tuberculosis were treated with IL-2 and SRHP regimen for one month. Conventional SRHP regimen alone was used as control (control group). Check the blood routine, liver function, serum creatinine, chest X-ray and sputum examination and record once every two months after treatment. Observe the degree of healing of empty lesions and sputum negative conversion rate. Results The patients in the treatment group had varying degrees of healing of the empty lesions, sputum was found to be negative for acid-fast bacilli, while the control group had no significant changes in the empty lesions and sputum negative conversion rate was lower. Conclusions Interleukin-2 is a safe and effective adjuvant treatment of empty tuberculosis.