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本文报道了毗喹酮治疗腹腔细粒棘球蚴病的动物实验和临床应用的研究情况。动物实验:腹腔接种取人肝的细粒棘球蚴原头蚴的小白鼠40只,分为4组,每组10只。在接种后110天,三组动物分别饲以含吡喹酮1,000ppm的食饵6天、12天、24天,一组作对照。于开始饲药后30天剖检,分别测量每只小白鼠接种生长的包虫囊的最大直径和重量及观察包虫囊的一般形态。结果:40只小白鼠全部感染。饲药各组小白鼠包虫囊最大直径和重量与对照组相比,经统计学处理,无显著性差异。但解剖时发现:自6天饲药组开始,包
This article reports the application of praziquantel in the treatment of abdominal granulomatous hydatid disease in animal experiments and clinical applications. Animal experiment: 40 mice were inoculated intraperitoneally with protozoa of Echinococcus granulosus and divided into 4 groups with 10 in each group. At 110 days after inoculation, three groups of animals were fed with 1,000 ppm of praziquantel, respectively, for 6 days, 12 days and 24 days, with one group as control. Thirty days after the start of feeding, autopsy was performed. The maximum diameter and weight of the hydatid vesicles inoculated with each mouse were measured, and the general morphology of the hydatid cysts was observed. Results: 40 mice were all infected. Compared with the control group, the maximum diameter and weight of the hydatid cyst of the mice in each group were statistically significant. However, when dissected, it was found that since the 6-day feeding group began to pack