论文部分内容阅读
绒毛取样法(CVS)作为妊娠开始三个月检测胎儿核型的技术已被广泛应用。但随着孕期的增加,细胞滋养层的分裂相逐渐减少,孕三月后CVS的应用受到限制。本研究目的为通过检测不同孕周实验结果的失败率,限制性胎盘镶嵌性的比率(CPM)以及假阳性、假阴性率等几项指标来评估孕三个月后使用CVS这项技术。 对1989～1997年间孕8～37周的2 424例CVS样本做回顾性研究。包括:CVS的适应征、所取绒毛组织的重量、孕周与核型结果的关系。依孕周将CVS样本分为4组。组1为孕14周以前,共1548例;组2为孕15～20周,共685例;组3力孕21～28周,共160例;组4为孕29周以后,共31例。
Villus sampling method (CVS) as the first trimester of pregnancy to detect fetal karyotype technology has been widely used. However, with the increase of pregnancy, the division of cytotrophoblast phase is gradually reduced, and the application of CVS after pregnancy is limited in March. The aim of this study was to evaluate the CVS technique after three months of pregnancy by measuring the failure rate of different gestational weeks, limiting placental inlaid ratio (CPM), and false positive and false negative rates. A retrospective study was performed on a total of 2 424 CVS samples from the 8th week to the 37th week from 1989 to 1997. Including: CVS indications, the weight of the villus taken, gestational age and karyotype results. According to gestational age CVS samples were divided into 4 groups. Group 1 was pregnant 14 weeks ago, a total of 1548 cases; group 2 for 15 to 20 weeks pregnant, a total of 685 cases; group 3 pregnant 21 to 28 weeks, a total of 160 cases; group 4 29 weeks after pregnancy, a total of 31 cases.