论文部分内容阅读
许多神经退行性疾病的发生是由蛋白质错误折叠引起的,这类疾病被称为蛋白质错误折叠病。蛋白质突变、泛素-蛋白酶和自噬功能的失常与蛋白质错误折叠的发生,异常蓄积和聚集有关。本文综述了蛋白质错误折叠和聚集的机制和神经退行性疾病的有关研究进展。
Many neurodegenerative diseases are caused by misfolding of proteins, a disease known as protein misfolding. Protein mutations, aberrations of ubiquitin-protease and autophagy, are associated with the occurrence of protein misfolding, abnormal accumulation and accumulation. This article reviews the mechanisms of protein misfolding and aggregation and neurodegenerative diseases.