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目的:观察软肝解毒煎预防治疗酒精性肝纤维化,阻断肝组织硬化,改善肝功能的作用。方法:选用纯系Wistar雄性大鼠,按体重随机均分为正常组、模型组、软肝解毒煎组3组。以正常组和模型组为对照,采用白酒ig造模,同时预防给予软肝解毒煎剂,剂量为21 g.kg-1,12周后,各组大鼠肝脏取材,应用光镜及电镜观察大鼠肝脏组织及超微结构,并测定血清单胺氧化酶(MAO)、羟脯氨酸(HP)含量。结果:软肝解毒煎组MAO,HP含量较模型组显著下降,均P<0.01,模型组肝组织大量胶原纤维增生,脂肪变性严重;软肝解毒煎组胶原纤维增生不明显,肝组织学及超微结构损伤显著减轻。结论:软肝解毒煎能有效预防酒精性肝纤维化。
Objective: To observe the effects of Ruangan Jiedu decoction in prevention and treatment of alcoholic liver fibrosis, blocking hepatic tissue sclerosis and improving liver function. Methods: Pure Wistar male rats were randomly divided into normal group, model group and Ruanjian Jiedu decoction group according to body weight. The normal group and the model group as a control, the use of liquor ig modeling, while preventing the soft liver detoxification decoction dose 21g.kg-1, 12 weeks after the rats were drawn from the liver, the application of light microscopy and electron microscopy The liver tissue and ultrastructure of rats were observed. The contents of monoamine oxidase (MAO) and hydroxyproline (HP) were measured. Results: The contents of MAO and HP in Ruiganjiedu decoction group were significantly lower than those in model group (all P <0.01). A large number of collagen fibers hyperplasia and steatosis were found in model group. Collagen fibrosis was not obvious in Ruangan Jiedu decoction group and liver histology Ultrastructural damage was significantly reduced. Conclusion: Ruangan Jiedu Jian can effectively prevent alcoholic liver fibrosis.