闭经的原因复杂,原发性闭经多属先天性发育异常,合并男性化者少见。继发性闭经合并有男性化者,多伴有高雄激素血症,必须根据男性化的程度,血中雄激素的种类及含量来判断其病因,才能获得正确的诊断。男性化体征常见者包括痤疮、多毛、皮下脂肪减少(消瘦或肌肉发达)、阴蒂肥大、喉结增粗、颞秃等。有的患者仅表现为闭经、不孕及无排卵,并无明显的男 The causes of amenorrhea complicated by primary congenital dysplasia are mostly congenital abnormalities, combined with masculine are rare. Secondary menopause combined with masculine, often accompanied by hyperandrogenism, must be based on the degree of masculinity, the type and content of blood androgen to determine its cause, in order to obtain a correct diagnosis. Common symptoms of masculine include acne, hirsutism, subcutaneous fat reduction (weight loss or muscular), clitoral hypertrophy, Adam’s apple thickening, temporal lobe and so on. Some patients showed only amenorrhea, infertility and anovulation, no obvious male