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研究了呫吨醇的合成方法,先以邻氯苯甲酸和苯酚为起始原料合成邻苯氧基苯甲酸,再在三氯氧磷的催化下环合合成呫吨酮,最后在锌粉的还原下合成呫吨醇。尤为关键的是在第二步中用三氯氧磷代替文献中使用的三氯化铝作为催化剂,降低了反应难度,第三步中使用锌粉代替文献中使用的硼氢化钠及钠汞齐作为还原剂,避免了对环境的污染,降低了成本。
The method for the synthesis of xanthenyl alcohol was studied. The o-phenoxybenzoic acid was firstly synthesized from o-chlorobenzoic acid and phenol, and then cyclized to xanthogenone under the action of phosphorus oxychloride. Finally, Under the reduction of synthetic xanthene alcohol. Particularly critical is the use of phosphorus oxychloride instead of the aluminum trichloride used in the literature as a catalyst in the second step, which reduces the difficulty of the reaction. The third step uses zinc powder instead of the sodium borohydride and sodium amalgam used in the literature As a reducing agent, to avoid the pollution of the environment, reducing costs.