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晚期乳腺癌患者通常发生骨转移。骨转移可导致骨痛、病理性骨折、神经压迫症状和高钙血症等并发症,严重影响病人的生活质量[1]。早期的诊断和有效的化疗放疗能显著降低原发性乳腺癌的死亡率,但不能延长晚期转移性乳腺癌患者的生存期。成人在正常生理情况下,骨重塑过程中成骨与溶骨保持平衡状态,与成骨细胞和破骨细胞活性密切相关。乳腺癌细胞通过刺激破骨细胞分化,增强活性和延长其生存期,从而促进骨吸收。所以降低破骨细胞活性和抑制其生存成为治疗乳腺癌骨转移的一个新靶标。
Patients with advanced breast cancer usually have bone metastases. Bone metastasis can lead to bone pain, pathological fractures, symptoms of nerve compression and hypercalcemia and other complications, seriously affecting the quality of life of patients [1]. Early diagnosis and effective chemotherapy and radiotherapy can significantly reduce the mortality of primary breast cancer, but can not extend the survival of patients with advanced metastatic breast cancer. Under normal physiological conditions, osteoblasts and osteolytic bone are maintained in equilibrium during bone remodeling in adults, which is closely related to the activity of osteoblasts and osteoclasts. Breast cancer cells promote bone resorption by stimulating osteoclast differentiation, enhancing activity and prolonging their survival. Therefore, reducing osteoclast activity and inhibiting its survival become a new target for the treatment of breast cancer bone metastases.