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口服药物肠道吸收的研究方法主要包括体外法、体内法和在体法,对这3种研究方法进行简要介绍。鉴于在体肠灌流法操作简便、技术成熟、可控性强,同时又保证了神经内分泌调节与淋巴液血液供应的完整性等特点,更能反映药物吸收的真实情况,因此重点介绍了在体肠灌流法,并对在体肠灌流法中使用的循环灌流法和单向灌流法常用的几种灌流液体积校正方法等进行综述,为研究口服药物肠道吸收试验设计提供借鉴和参考。为保证试验的可操作性和实验结果的准确性,认为应根据所研究药品的性质、实验要求、试验条件等多方面因素综合考虑,选择适宜的试验方法,进而为药物剂型的开发和临床合理用药提供依据。
The research methods of intestinal absorption of oral drugs mainly include in vitro method, in vivo method and in vivo method, and briefly introduce the three research methods. In view of the advantages of simple operation, mature technology and strong controllability in the intestine intestinal perfusion method, while ensuring the neuroendocrine regulation and the integrity of the blood supply of lymphatic fluid and so on, and better reflect the real situation of drug absorption, Intestinal perfusion method, and in the intestine perfusion method used in the perfusion method and one-way perfusion fluid volume method commonly used several volume correction methods are reviewed for the study of oral drug intestinal absorption test design and provide reference. In order to ensure the operability of the experiment and the accuracy of the experimental results, it is considered that the appropriate experimental methods should be selected according to the factors such as the nature of the drugs studied, the experimental requirements and the experimental conditions, so that the development and clinical rationality of the pharmaceutical dosage forms Drugs provide the basis.