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报道了烯烃分子间的氧化双官能团化反应,用金属钯作为金属催化剂,三价碘为氧化剂,氟化银为氟源,磺酰胺类为亲核试剂,实现了苯乙烯的分子间胺氟化反应,得到α-F代苯乙胺类化合物;反应是经过烯烃的反马氏氮钯化得到碳钯键,再经过三价碘氧化成高价钯的中间体来形成C—F键,在分子中的特定位置引入氟原子.该反应的一个特点是选择性地得到反马氏胺氟产物.
Reported the oxidation of bifunctional alkene oxidation reaction between molecules, the use of metal palladium as a metal catalyst, trivalent iodine as an oxidant, silver fluoride as a fluorine source, sulfonamides as nucleophiles to achieve a styrene intermolecular amine fluoride Reaction, to obtain α-F-phenethylamine compounds; the reaction is through the olefin anti-horsemanium palladium to obtain carbon-palladium bond, and then trivalent iodide to form a high-valent palladium intermediate to form a C-F bond in the molecule A fluorine atom is introduced at a specific position in the reaction vessel. A feature of this reaction is the selective reaction of the anti-mequine fluoride product.