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目的：观察醋己氨酸锌（ＺＡ）抗大鼠或小鼠实验性胃溃疡作用。方法与结果：设ＺＡ，雷尼替丁（Ｒａｎ）和空白对照组。ＺＡ２５，５０，１００ｍｇ／ｋｇ，ｉｐ和Ｒａｎ１２．５，２５，５０ｍｇ／ｋｇｉｐ均能明显降低幽门结扎大鼠的胃酸和胃蛋白酶活力（Ｐ＜０．０１），ＺＡ还能明显提高胃液中己糖胺含量，对ＨＣｌ０．６ｍｏｌ／Ｌ，２５％ＮａＣｌ和无水乙醇所致小鼠胃溃疡有明显的阻抑作用，ＺＡｉｇ７５－３００ｍｇ／ｋｇ明显抑制大鼠冷应激和束水应激诱发的胃溃疡及胃粘膜肥大细胞数的下降，但Ｒａｎ对后者没有抑制作用。结论：ＺＡ对大鼠或小鼠实验性胃溃疡有明显的阻抑作用。
Objective: To observe the effect of zinc acetate histidine (ZA) on experimental gastric ulcer in rats or mice. Methods and Results: ZA, ranitidine (Ran) and blank control group were established. ZA25,50,100mg / kg, ip and Ran12.5,25,50mg / kg ip can significantly reduce pylorus ligation of gastric acid and pepsin activity (P <0.01), ZA can significantly increase the hexose in the gastric juice Amine content significantly inhibited gastric ulcer in mice induced by HCl0.6mol / L, 25% NaCl and ethanol, while ZAig75-300mg / kg significantly inhibited gastric ulcer induced by cold stress and water stress in rats And gastric mucosal mast cells decreased, but Ran has no inhibitory effect on the latter. Conclusion: ZA has a significant inhibitory effect on experimental gastric ulcer in rats or mice.