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本工作测定了20例长期服苯妥英钠的癫痫患者血DPH、25OH D_3、cAMP、Ca、P、AKP、离子钙;尿cAMP、Ca、P及羟脯氨酸水平;桡、尺骨骨矿物含量和骨密度,并设立相应健康人作为对照组。测定结果为:癫痫组25OHD_3水平显著低于对照;全部患者中血钙降低者占20％;血磷降低者低占25％;尿钙、磷降低者占45％和55％;血离子钙降低者占85％;AKP和尿羟脯氨酸升高各占10％。癫痫组桡骨骨矿物含量、骨密度及尺骨的骨密度值显著低于对照组。
In this study, we measured the blood levels of DPH, 25OH D_3, cAMP, Ca, P, AKP, ionized calcium, urinary cAMP, Ca, P and hydroxyproline in 20 chronic phenytoin- Bone mineral density, and set up the corresponding healthy people as a control group. The results showed that the level of 25OHD_3 in epilepsy group was significantly lower than that in control group; the level of serum calcium decreased 20% in all patients; the rate of serum phosphorus decreased 25%; the level of urinary calcium and phosphorus decreased 45% and 55% Accounted for 85%; AKP and urinary hydroxyproline increased by 10%. Epilepsy group radius bone mineral content, bone mineral density and ulnar bone mineral density was significantly lower than the control group.