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泛素-蛋白酶体途径是真核细胞内重要的蛋白质调控系统,参与调节细胞周期进程、细胞增生与分化,以及信号传导等多种细胞生理过程,因此,细胞内蛋白泛素化降解是蛋白质重要的转录后修饰方式。EBV编码多种病毒蛋白,通过泛素．蛋白酶体途径调节病毒的潜伏,使病毒能在免疫活性较高的宿主体中存活。LMP1和LMP2A可能作为泛素．蛋白酶体途径的底物而受其调控,EBNA1则充当蛋白酶体降解过程中的阻滞剂。对它们在该途径中不同作用的深入了解将促使我们发展治疗EBV相关癌症的新策略。
Ubiquitin-proteasome pathway is an important protein regulation system in eukaryotic cells, which is involved in many cell physiological processes such as cell cycle progression, cell proliferation and differentiation, and signal transduction. Therefore, intracellular protein ubiquitination is protein important Post-transcriptional modification. EBV encodes many viral proteins, through ubiquitin. The proteasome pathway regulates the latency of the virus, allowing the virus to survive in the more immunocompetent host. LMP1 and LMP2A may act as ubiquitin. Proteasome pathway substrates are regulated by it, and EBNA1 acts as a blocker in proteasomal degradation. A deep understanding of their different roles in this pathway will prompt us to develop new strategies for the treatment of EBV-related cancers.