1病例报告患者男,33岁。脑胶质瘤手术后4周开始接受头颈部放疗,放疗期间仍遵外科医嘱继续口服丙戊酸钠缓释片抗癫治疗。放疗3周后发现头颈部出现大片红疹,遂立即停止放疗,但胸背部、会阴部、双上肢继续出现大片红色斑丘疹,并逐渐融合、破溃。急请皮肤科会诊,诊断为剥脱性皮炎,不除外药物所致。立即停用丙戊酸钠缓释片,加用地塞米松及抗生素治疗,精心护理受损皮肤。但病情持续加重,皮肤呈片状剥脱,眼结膜充血水 1 case report Patient male, 33 years old. Glioma surgery began 4 weeks after surgery for head and neck radiotherapy, radiotherapy continued compliance with the surgeon continued oral sodium valproate sustained-release tablets antiepileptic treatment. Three weeks after radiotherapy, a large rash occurred on the head and neck, and immediately stopped radiotherapy. However, large red rash continued to appear in the back of the chest, the perineum, and both upper extremities and gradually merged and ruptured. Urgent dermatology consultation, diagnosis of exfoliative dermatitis, not due to drugs. Immediate withdrawal of sodium valproate sustained release tablets, plus dexamethasone and antibiotics, meticulous care of damaged skin. However, the condition continued to aggravate, flaky skin flakes, conjunctival congestion of water