对无数糖尿病人来说,设计口服胰岛素的方法以代替注射给药,有很大好处。但这种努力迄今未获成功,主要障碍是:(1)胰岛素在胃肠道内被消化灭活;(2)对于比三肽大的肽类从肠道转运至血液的机制缺乏认识。近年发现胰岛素能渗透正常人和糖尿病人的肠道、呼吸道及口腔粘膜,促使作者重新研究口服肽类药物的方法。用不受消化酶影响的多聚物膜包裹肽类药物能预防消化酶的作用,若此膜在结肠内被正常菌群降解破坏,药物即释入不分泌消化酶的肠段部份,或作用于局部,或吸收进入血液。偶氮芳香族化合物R—C_6H_4—N=N—C_6H_4—R 能被肠内菌群还原裂解,生成一对芳 For millions of people with diabetes, the design of oral insulin injections instead of injection, a great benefit. However, such efforts have so far failed, with major hurdles being: (1) Insulin is digested and inactivated in the gastrointestinal tract; and (2) there is a lack of understanding of the mechanisms by which larger peptides are transported from the gut to the bloodstream. In recent years, insulin was found to penetrate the gut, respiratory and oral mucosa of normal and diabetic people, prompting the authors to re-examine the oral peptide drugs. Peptides coated with a polymeric membrane that is unaffected by digestive enzymes prevent digestive enzymes. If the membrane is destroyed by normal flora in the colon, the drug is released into the gut segment that does not digest the digestive enzymes or Role in the local, or absorbed into the blood. Azo aromatics R-C_6H_4-N = N-C_6H_4-R can be reduced by the intestinal flora cleavage to generate a pair of aromatic