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研究Kishner-Wolff改良法应用于双酮,酮醇,酮酸及α,β-不饱和羰基化合物: 1.α-双酮、联苯甲酰(Ⅰ)及α-酮醇、安息香(Ⅶ)能正常还原,产率甚佳,但碱须后加.并解释α-酮醇、安息香(Ⅶ)变成对应的饱和烃二苯乙烷(Ⅱ)的反应机理. 2.α-酮酸、苯代焦葡萄酸(ⅩⅫ)及γ-酮酸苯甲酰丙酸(ⅩⅩⅩ)能正常还原,产率尚佳. 3.β-双酮、双苯甲酰甲烷(ⅩⅩⅣ),γ-双酮、双苯甲酰乙烷(ⅩⅩⅧ)及β-酮酸、苯甲酰乙酸(ⅩⅩⅥ)均不能正常还原,而得含氮环状化合物3,5-二苯基吡唑(ⅩⅩⅤ),3,6-二苯基哒嗪(ⅩⅩⅨ)及3-苯基吡唑酮(ⅩⅩⅦ). 4.α,β-不饱和醛,糠醛(XLI)及桂皮醛(XLIII)~([1c])均能正常还原,但α,β-不饱和酮,亚苄基苯乙酮(XXX)及亚苄基丙酮(XXXV)均不能正常还原,而得环丙烷衍生物,1,3-二苯基环丙烷(XXXIV)及1-苯基3-甲基环丙烷(XXXVII).至于异丙烯基丙酮(XXXVIII)则得吡唑啉化合物(XXXIX).
Study Kishner-Wolff modified method applied to the diketone, ketol, keto acid and α, β-unsaturated carbonyl compounds: 1. α-diketone, bibenzoyl (Ⅰ) and α-ketol, benzoin Can be normally restored, the yield is very good, but the alkali shall be added afterwards, and explain the reaction mechanism of α-ketoalcohol and benzoin (VII) into the corresponding saturated hydrocarbon diphenylethane (Ⅱ) Benzoyl pyroglutamic acid (Ⅹ Ⅻ) and γ-keto acid benzoyl propionic acid (Ⅹ Ⅹ X) can be normally reduced, the yield is still good 3. β-diketone, dibenzoylmethane (XXIV), γ- , Dibenzoyl ethane (XXVIII), β-keto acid and benzoylacetic acid (XXVI) can not be normally reduced to give 3,5-diphenylpyrazole (XXV), which is a nitrogen-containing cyclic compound, 6-diphenylpyridazine (XXIX) and 3-phenylpyrazolone (XXVII) 4.α, β-unsaturated aldehyde, furfural (XLI) and cinnamaldehyde (XLIII) Normal reduction, but α, β-unsaturated ketone, benzylidene acetophenone (XXX) and benzylidene acetone (XXXV) can not be normal reduction, cyclopropane derivatives, 1,3-diphenyl cyclopropane (XXXIV) and 1-phenyl 3-methylcyclopropane (XXXVII) As for isopropenyl acetone (XXXVIII) pyrazoline compounds (XXXIX) are obtained.